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KMID : 0043320070300020172
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Archives of Pharmacal Research
2007 Volume.30 No. 2 p.172 ~ p.176
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Isolation of Constituents and Anti-complement Activity from Acer okamotoanum
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Jin WenYi
Min Byung-Sun
Lee Jong-Pill
Thuong Phuong Thien
Lee Hyeong-Kyu
Song Kyung-Sik
Seong Yeon-Hee
Bae Ki-Hwan
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Abstract
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A novel acylated sterol glucoside (1) along with four known compounds, β-amyrin acetate (2), 3β,24-dihydroxytaraxer-14-ene (3), cleomiscosin A (4), and cleomiscosin C (5), were isolated from the leaf and twig of Acer okamotoanum Nakai (Aceraceae). The structure of the new compound was determined to be β-sitosterol glucoside-3’-O-hexacosanoicate based on chemical and spectroscopic analyses. In addition, the novel compound was found to exhibit a significant inhibitory effect (IC50 value of 0.2 μM) on the complement system activated by the classical pathway.
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KEYWORD
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Acer okamotoanum, Aceraceae, Acylated sterol glucoside, β-Sitosterol glucoside-3’-O-hexacosanoicate, Anti-complement activity
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